Hypercoagulability and Vascular Disease

Hematol Oncol Clin North Am. 2018 Apr;32(2):237-245. doi: 10.1016/j.hoc.2017.11.001. Epub 2017 Dec 1.

Abstract

The presence of a high incidence of thrombotic events, mainly in nontransfusion-dependent β-thalassemia syndromes, has led to the identification of a hypercoagulable state in thalassemia patients. This article highlights the mechanisms leading to hypercoagulability in thalassemia. It also discusses the clinical experience and available evidence on prevention and management approaches.

Keywords: Cerebrovascular disease; Hypercoagulable state; Pulmonary hypertension; Thrombosis.

Publication types

  • Review

MeSH terms

  • Disease Management
  • Humans
  • Thalassemia / complications*
  • Thrombophilia / diagnosis
  • Thrombophilia / etiology*
  • Thrombophilia / prevention & control
  • Thrombophilia / therapy
  • Vascular Diseases / diagnosis
  • Vascular Diseases / etiology*
  • Vascular Diseases / prevention & control
  • Vascular Diseases / therapy