Exploration research on synthesis and application of a new dye containing di-2-picolyamine

Huihui Zhang; Zeyue Wei; Ying Xia; Min Fang; Weiju Zhu; Xingyuan Yang; Fei Li; Yupeng Tian; Xuanjun Zhang; Hongping Zhou

doi:10.1016/j.saa.2018.02.023

Exploration research on synthesis and application of a new dye containing di-2-picolyamine

Spectrochim Acta A Mol Biomol Spectrosc. 2018 May 5:196:256-261. doi: 10.1016/j.saa.2018.02.023. Epub 2018 Feb 9.

Authors

Huihui Zhang¹, Zeyue Wei¹, Ying Xia¹, Min Fang¹, Weiju Zhu¹, Xingyuan Yang², Fei Li¹, Yupeng Tian¹, Xuanjun Zhang³, Hongping Zhou⁴

Affiliations

¹ College of Chemistry and Chemical Engineering, Anhui University and Key Labotatory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, 230601 Hefei, PR China.
² Faculty of Health Science, Anhui University, Hefei 230601, PR China.
³ Faculty of Health Science, University of Macau, Taipa, Macau, SAR, PR China.
⁴ College of Chemistry and Chemical Engineering, Anhui University and Key Labotatory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, 230601 Hefei, PR China. Electronic address: zhpzhp@263.net.

PMID: 29454254
DOI: 10.1016/j.saa.2018.02.023

Abstract

A newly designed fluorescence dye L based on di-2-picolyamine (DPA) moiety as a chelator was obtained under the protection of N₂ at 120°C, and KI as catalyst with relatively better yield. More interestingly, L not only could selectively and sensitively detect Cu²⁺ ions in aqueous medium but also examine the Cu²⁺ ions of the actual water samples. Nevertheless, L could be visual in Hela cells with excellent cell permeability, viz, monitoring exogenous Cu²⁺ ions as well as realizing an "on-off-on" process.

Keywords: Bio-imaging; Fluorescence; di-2-picolyamine.

MeSH terms

Amines / chemistry*
Copper / analysis
Fluorescent Dyes / chemical synthesis*
Fluorescent Dyes / chemistry*
HeLa Cells
Humans
Microscopy, Fluorescence
Picolinic Acids / chemistry*
Sensitivity and Specificity

Substances

2,2'-dipicolylamine
Amines
Fluorescent Dyes
Picolinic Acids
Copper