Abstract
STIM1 and STIM2 are endoplasmic reticulum Ca2+ sensors that serve multi‐faceted roles in signal transduction in a wide variety of different cell types. In this issue of The EMBO Journal, Motiani et al define and characterize the ability of STIM1 to control cAMP generation in a new context, melanin production (Motiani et al, 2018), offering new insights into the physiological role of STIM1.