Feasibility of high spatiotemporal resolution for an abbreviated 3D radial breast MRI protocol

Jorge E Jimenez; Roberta M Strigel; Kevin M Johnson; Leah C Henze Bancroft; Scott B Reeder; Walter F Block

doi:10.1002/mrm.27137

Feasibility of high spatiotemporal resolution for an abbreviated 3D radial breast MRI protocol

Magn Reson Med. 2018 Oct;80(4):1452-1466. doi: 10.1002/mrm.27137. Epub 2018 Feb 14.

Authors

Jorge E Jimenez¹, Roberta M Strigel^{1

2

3}, Kevin M Johnson¹, Leah C Henze Bancroft², Scott B Reeder^{1

2

4

5

6}, Walter F Block^{1

2

4}

Affiliations

¹ Department of Medical Physics, University of Wisconsin, Madison, Wisconsin.
² Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
³ Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin.
⁴ Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin.
⁵ Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
⁶ Department of Emergency Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Abstract

Purpose: To develop a volumetric imaging technique with 0.8-mm isotropic resolution and 10-s/volume rate to detect and analyze breast lesions in a bilateral, dynamic, contrast-enhanced MRI exam.

Methods: A local low-rank temporal reconstruction approach that also uses parallel imaging and spatial compressed sensing was designed to create rapid volumetric frame rates during a contrast-enhanced breast exam (vastly undersampled isotropic projection [VIPR] spatial compressed sensing with temporal local low-rank [STELLR]). The dynamic-enhanced data are subtracted in k-space from static mask data to increase sparsity for the local low-rank approach to maximize temporal resolution. A T₁ -weighted 3D radial trajectory (VIPR iterative decomposition with echo asymmetry and least squares estimation [IDEAL]) was modified to meet the data acquisition requirements of the STELLR approach. Additionally, the unsubtracted enhanced data are reconstructed using compressed sensing and IDEAL to provide high-resolution fat/water separation. The feasibility of the approach and the dual reconstruction methodology is demonstrated using a 16-channel breast coil and a 3T MR scanner in 6 patients.

Results: The STELLR temporal performance of subtracted data matched the expected temporal perfusion enhancement pattern in small and large vascular structures. Differential enhancement within heterogeneous lesions is demonstrated with corroboration from a basic reconstruction using a strict 10-second temporal footprint. Rapid acquisition, reliable fat suppression, and high spatiotemporal resolution are presented, despite significant data undersampling.

Conclusion: The STELLR reconstruction approach of 3D radial sampling with mask subtraction provides a high-performance imaging technique for characterizing enhancing structures within the breast. It is capable of maintaining temporal fidelity, while visualizing breast lesions with high detail over a large FOV to include both breasts.

Keywords: bilateral breast; compressed sensing; dynamic contrast-enhanced MRI; local low-rank; parallel imaging; radial sampling.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Breast / diagnostic imaging*
Breast Neoplasms / diagnostic imaging
Contrast Media
Feasibility Studies
Female
Humans
Image Interpretation, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods*
Magnetic Resonance Imaging / methods*
Signal-To-Noise Ratio

Substances

Contrast Media

Abstract

Publication types

MeSH terms

Substances

Grants and funding