Soliseptide A, A Cyclic Hexapeptide Possessing Piperazic Acid Groups from Streptomyces solisilvae HNM30702

Junfeng Wang; Ziwen Cong; Xiaolong Huang; Chenxi Hou; Weihao Chen; Zhengchao Tu; Dongyi Huang; Yonghong Liu

doi:10.1021/acs.orglett.8b00142

Soliseptide A, A Cyclic Hexapeptide Possessing Piperazic Acid Groups from Streptomyces solisilvae HNM30702

Org Lett. 2018 Mar 2;20(5):1371-1374. doi: 10.1021/acs.orglett.8b00142. Epub 2018 Feb 14.

Authors

Junfeng Wang¹, Ziwen Cong^{1

2}, Xiaolong Huang², Chenxi Hou¹, Weihao Chen^{1

3}, Zhengchao Tu⁴, Dongyi Huang², Yonghong Liu^{1

3}

Affiliations

¹ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301, People's Republic of China.
² Institute of Tropical Agriculture and Forestry, Hainan University , Haikou 570228, People's Republic of China.
³ University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
⁴ Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China.

PMID: 29441782
DOI: 10.1021/acs.orglett.8b00142

Abstract

Soliseptide A (1), a cyclic hexapeptide possessing piperazic acid groups, together with two known azalomycin derivatives (2 and 3) were isolated from Streptomyces solisilvae HNM30702. Their structures were determined through spectroscopic methods and single crystal X-ray diffraction analysis. Soliseptide A (1) possessed a cyclic hexapeptide core featured with two piperazic acid units rarely discovered in nature, and exhibited weak antibacterial and antiviral activities. Besides, compounds 2 and 3 displayed significant fungicidal effects.

Publication types

Research Support, Non-U.S. Gov't