Kaurene as the major constituent of the essential oils of the narcotic plant, Khat (Catha edulis Forsk)

Nat Prod Res. 2019 Jan;33(1):126-129. doi: 10.1080/14786419.2018.1437424. Epub 2018 Feb 13.

Abstract

Khat (Catha edulis Forsk) is a narcotic plant which contains significant amounts of amphetamines, like alkaloids. Herein, analysis of the essential oil composition showed that Khat has useful volatile chemicals in addition to its alkaloids. Results indicated that among 35 identified constituents including mono and sesquiterpenes, the diterpene kaurene, comprises the major part of the essential oil, around 50 percent of total. Kaurene is known as a potent biological agent for the treatment of cancer patients. The presence of kaurene at high levels indicates that the essential oil of Catha edulis can potentially be more effectively exploited rather than its narcotic stimulant amphetamine-like alkaloids.

Keywords: amphetamines; cathinone; essential oils composition; kaurene.

MeSH terms

  • Alkaloids / analysis
  • Amphetamines
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Catha / chemistry*
  • Diterpenes, Kaurane / analysis*
  • Humans
  • Narcotics / chemistry*
  • Oils, Volatile / analysis
  • Oils, Volatile / chemistry*
  • Plant Extracts / analysis

Substances

  • Alkaloids
  • Amphetamines
  • Antineoplastic Agents, Phytogenic
  • Diterpenes, Kaurane
  • Narcotics
  • Oils, Volatile
  • Plant Extracts
  • kaurene