Abstract
Herein, the photosensitizer indocyanine green (ICG) is used to induce the self-assembly of antigens to form nanovaccines. Under near-infrared (NIR) laser irradiation, reactive oxygen species can be generated by nanovaccines to disrupt the membranes of endo/lysosomes, which helps to release antigens into the cytosol efficiently, thereby enhancing antigen cross-presentation and anti-cancer immunity. To the best of our knowledge, this study represents the first example of ICG as a biocompatible adjuvant to improve cancer vaccine efficacy.
MeSH terms
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Animals
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Antigens / chemistry*
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Antigens / metabolism
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Antigens / therapeutic use
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Cancer Vaccines / chemistry*
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Cancer Vaccines / metabolism
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Cancer Vaccines / therapeutic use
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Cell Line, Tumor
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Humans
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Immunotherapy / methods*
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Indocyanine Green / chemistry*
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Indocyanine Green / pharmacology
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Mice
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Neoplasms, Experimental / therapy*
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / pharmacology
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Protein Multimerization / drug effects
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Protein Multimerization / radiation effects
Substances
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Antigens
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Cancer Vaccines
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Photosensitizing Agents
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Indocyanine Green