Regulation of hematopoiesis by the chemokine system

Cytokine. 2018 Sep:109:76-80. doi: 10.1016/j.cyto.2018.01.021.

Abstract

Although chemokines are best known for their role in directing cell migration, accumulating evidence indicate their involvement in many other processes. This review focus on the role of chemokines in hematopoiesis with an emphasis on myelopoiesis. Indeed, many chemokine family members are an important component of the cytokine network present in the bone marrow that controls proliferation, retention, and mobilization of hematopoietic progenitors.

Keywords: Chemokine receptors; Chemokines; Hematopoiesis; Myelopoiesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Movement / physiology
  • Cell Proliferation / physiology
  • Chemokines / metabolism*
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / physiology
  • Humans
  • Inflammation / pathology
  • Myelopoiesis / physiology*
  • Receptors, Chemokine / metabolism*
  • Signal Transduction

Substances

  • Chemokines
  • Receptors, Chemokine