Normal saline for intravenous fluid therapy in critically ill patients

Fei-Hu Zhou; Chao Liu; Zhi Mao; Peng-Lin Ma

doi:10.1016/j.cjtee.2017.04.012

Normal saline for intravenous fluid therapy in critically ill patients

Chin J Traumatol. 2018 Feb;21(1):11-15. doi: 10.1016/j.cjtee.2017.04.012. Epub 2018 Jan 31.

Authors

Fei-Hu Zhou¹, Chao Liu¹, Zhi Mao¹, Peng-Lin Ma²

Affiliations

¹ Department of Critical Care Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
² Department of Critical Care Medicine, 309th Hospital of Chinese People's Liberation Army, Beijing 100091, China. Electronic address: mapenglin1@163.com.

Abstract

The efficacy and safety of normal saline (NS) for fluid therapy in critically ill patients remain controversy. In this review, we summarized the evidence of randomized controlled trials (RCTs) which compared NS with other solutions in critically ill patients. The results showed that when compared with 6% hydroxyethyl starch (HES), NS may reduce the onset of acute kidney injury (AKI). However, there is no significant different in mortality and incidence of AKI when compared with 10% HES, albumin and buffered crystalloid solution. Therefore, it is important to prescribe intravenous fluid for patients according to their individual condition.

Keywords: Critical care; Fluid resuscitation; Normal saline.

Publication types

Review

MeSH terms

Albumins / therapeutic use
Critical Illness*
Crystalloid Solutions
Fluid Therapy / methods*
Humans
Hydroxyethyl Starch Derivatives / therapeutic use
Isotonic Solutions / therapeutic use
Sodium Chloride / therapeutic use*

Substances

Albumins
Crystalloid Solutions
Hydroxyethyl Starch Derivatives
Isotonic Solutions
Sodium Chloride