4-Hydroxybenzoic acid for multiple system atrophy?

Abstract

Increasing evidence supports a link between multiple system atrophy and coenzyme Q₁₀ (CoQ₁₀) biosynthesis. However, so far this knowledge was not translated into tangible benefits for affected patients. Poor bioavailability of oral CoQ₁₀ might constitute a major problem. Current research suggests that 4-hydroxybenzoic acid might constitute an interesting alternative treatment option.

Keywords: COQ2; Coenzyme Q(10); Neurodegeneration; Therapy.