Objective: To investigate the role of donor human milk in the prevention of nosocomial infection in very low birth weight infants. MeETHODS: A total of 105 hospitalized preterm infants with a very low birth weight were enrolled. They were classified into mother's own milk feeding group, donor human milk feeding group, and preterm formula feeding group, with 35 infants in each group. The three groups were compared in terms of incidence rates of nosocomial infection, necrotizing enterocolitis, and feeding intolerance, time to full enteral feeding, and early growth indices.
Results: Compared with the preterm formula feeding group, the donor human milk feeding group and the mother's own milk feeding group had significantly lower incidence rates of nosocomial infection and necrotizing enterocolitis and shorter time to full enteral feeding (P<0.05). There were no significant differences in head circumference, body length, and weight growth velocity among the three groups.
Conclusions: Donor human milk can be used in case of a lack of mother's own milk and may help to reduce nosocomial infection.
目的: 探讨捐献母乳在预防极低出生体重儿院内感染中的作用。
方法: 将105例极低出生体重住院早产儿纳入研究，根据其所接受的喂养方式分为亲母母乳、捐献母乳、早产儿配方奶喂养组，每组各35例。比较3组院内感染发生率、坏死性小肠结肠炎发生率、喂养不耐受发生率以及达到全肠道喂养时间、早期生长指标。
结果: 与配方奶组比较，捐献母乳组和亲母母乳组患儿院内感染及坏死性小肠结肠发生率明显降低，且捐献母乳组和亲母母乳组达到全肠道喂养的时间短于配方奶组，差异均有统计学意义（P < 0.05）。3组患儿头围、身长、体重增长速率比较差异无统计学意义。
结论: 极低出生体重儿在亲母母乳不足时可以采用捐献母乳替代喂养，有助于降低院内感染的发生。