Prognostic significance of SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in adult de novo acute myeloid leukemia

Natasa Tosic; Isidora Petrovic; Natasa Kovacevic Grujicic; Slobodan Davidovic; Marijana Virijevic; Nada Suvajdzic Vukovic; Sonja Pavlovic; Milena Stevanovic

doi:10.1016/j.leukres.2018.02.001

Prognostic significance of SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in adult de novo acute myeloid leukemia

Leuk Res. 2018 Apr:67:32-38. doi: 10.1016/j.leukres.2018.02.001. Epub 2018 Feb 6.

Authors

Natasa Tosic¹, Isidora Petrovic², Natasa Kovacevic Grujicic², Slobodan Davidovic², Marijana Virijevic³, Nada Suvajdzic Vukovic³, Sonja Pavlovic⁴, Milena Stevanovic²

Affiliations

¹ Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia. Electronic address: nmtosic@sezampro.rs.
² Laboratory for Human Molecular Genetics, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia.
³ Clinic of Hematology, Clinical Center of Serbia, Belgrade, Serbia; School of Medicine University of Belgrade, Belgrade, Serbia.
⁴ Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia.

PMID: 29428447
DOI: 10.1016/j.leukres.2018.02.001

Abstract

Aberrant expression of different SOX (SRY-related high mobility group (HMG) box) genes has been observed in number of tumors but, little is known about their expression patterns in hematological malignancies, especially in acute myeloid leukemia (AML). In this study we investigated SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in 50 de novo adult AML patients and correlated our findings with known clinical and molecular prognostic markers of the disease. We have found that these genes are overexpressed in 10-22% of patients and preliminary findings suggest that high expression level of these genes may have prognostic significance in AML patients. This is the first study focused on examining the expression level of SOX2, SOX3, SOX11, SOX14 and SOX18 genes in AML patients. Although this is a relatively limited study, initial findings indicate the need for further investigation of these genes, their potential roles in leukemia pathogenesis as well as prognosis in AML patients.

Keywords: Acute myeloid leukemia; Prognosis; SOX genes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Biomarkers, Tumor / genetics
Disease-Free Survival
Female
Gene Expression Profiling*
Humans
Leukemia, Myeloid, Acute / genetics*
Male
Mutation*
Nuclear Proteins / genetics
Nucleophosmin
Prognosis
SOXB1 Transcription Factors / genetics*
SOXB2 Transcription Factors / genetics*
SOXC Transcription Factors / genetics*
SOXF Transcription Factors / genetics*
Survival Analysis
Young Adult
fms-Like Tyrosine Kinase 3 / genetics

Substances

Biomarkers, Tumor
Nuclear Proteins
SOX11 protein, human
SOX14 protein, human
SOX18 protein, human
SOX2 protein, human
SOX3 protein, human
SOXB1 Transcription Factors
SOXB2 Transcription Factors
SOXC Transcription Factors
SOXF Transcription Factors
Nucleophosmin
FLT3 protein, human
fms-Like Tyrosine Kinase 3