Diversity of circulating tumor cells in peripheral blood: Detection of heterogeneous BRAF mutations in a patient with advanced melanoma by single-cell analysis

J Dermatol Sci. 2018 May;90(2):211-213. doi: 10.1016/j.jdermsci.2018.01.011. Epub 2018 Feb 1.

Authors

Yukiko Kiniwa¹, Kenta Nakamura¹, Asuka Mikoshiba¹, Yasuyuki Akiyama², Atsushi Morimoto², Ryuhei Okuyama³

Affiliations

¹ Department of Dermatology, Shinshu University School of Medicine, Japan.
² Life Science Research Laboratory, Tosoh Corporation, Japan.
³ Department of Dermatology, Shinshu University School of Medicine, Japan. Electronic address: rokuyama@shinshu-u.ac.jp.

PMID: 29426605
DOI: 10.1016/j.jdermsci.2018.01.011

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Aged
Biomarkers, Tumor / blood
Biomarkers, Tumor / genetics*
Circulating Tumor DNA / blood
Circulating Tumor DNA / genetics*
DNA Mutational Analysis / methods*
Genetic Predisposition to Disease
Humans
Male
Melanoma / blood
Melanoma / genetics*
Melanoma / secondary
Mutation*
Neoplastic Cells, Circulating / chemistry*
Neoplastic Cells, Circulating / pathology
Phenotype
Proto-Oncogene Proteins B-raf / blood
Proto-Oncogene Proteins B-raf / genetics*
Single-Cell Analysis*
Skin Neoplasms / blood
Skin Neoplasms / genetics*
Skin Neoplasms / pathology
Tomography, X-Ray Computed

Substances

Biomarkers, Tumor
Circulating Tumor DNA
BRAF protein, human
Proto-Oncogene Proteins B-raf