[Enzymatic production of arginine derivatives: a review]

Sheng Wu Gong Cheng Xue Bao. 2018 Feb 25;34(2):165-176. doi: 10.13345/j.cjb.170163.
[Article in Chinese]

Abstract

L-arginine (L-Arg) is an alkaline amino acid that possesses various function groups and acts as an important precursor for useful chemical synthesis. L-Arg derivatives are widely applied in pharmaceutical, food and cosmetic industries. Environment friendly and cost-effective production of L-Arg derivatives by enzymatic catalysis provides significant advantages over chemical synthesis and microbial fermentation. In this article, several typical L-Arg derivatives and their enzymatic production processes are highlighted. Furthermore, prospect is also addressed about enzymatic production of L-Arg derivatives.

L-精氨酸是一种碱性氨基酸,具有多样化的官能团,是合成多种有用化合物的前体,其衍生物广泛应用于医疗、食品和化妆品等领域。L-精氨酸衍生物的合成方法有化学法、发酵法和酶法。在当前绿色经济和可持续发展的背景下,对比各种生产方法,生物酶法合成L-精氨酸衍生物具有明显优势。因此本文重点介绍了L-精氨酸衍生化的典型产品和合成技术,并介绍了生物酶法合成L-精氨酸衍生物未来可能的发展方向。.

Keywords: L-arginine; agmatine; citrulline; derivatization; enzymatic production; ornithine.

Publication types

  • Review

MeSH terms

  • Arginine / biosynthesis*
  • Ligases / metabolism*

Substances

  • Arginine
  • Ligases