Rigenolides D-H, norsecoiridoid and secoiridoids from Gentiana rigescens Franch

Yoshihiro Suyama; Naonobu Tanaka; Kazuyoshi Kawazoe; Kotaro Murakami; Shun-Lin Li; Han-Dong Sun; Yoshiki Kashiwada

doi:10.1007/s11418-018-1181-2

Rigenolides D-H, norsecoiridoid and secoiridoids from Gentiana rigescens Franch

J Nat Med. 2018 Mar;72(2):576-581. doi: 10.1007/s11418-018-1181-2. Epub 2018 Feb 8.

Authors

Yoshihiro Suyama¹, Naonobu Tanaka^{1

2}, Kazuyoshi Kawazoe³, Kotaro Murakami⁴, Shun-Lin Li⁵, Han-Dong Sun⁵, Yoshiki Kashiwada⁶

Affiliations

¹ Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
² Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, 770-8513, Japan.
³ School of Pharmacy, Showa University, Shinagawa, 142-8555, Japan.
⁴ Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, 862-0082, Japan.
⁵ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kumming Institute of Botany, Chinese Academy of Sciences, Kumming, 650201, China.
⁶ Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan. kasiwada@tokushima-u.ac.jp.

PMID: 29423590
DOI: 10.1007/s11418-018-1181-2

Abstract

Five new compounds, rigenolides D-H (1-5), were isolated from the aerial parts of Gentiana rigescens Franch. Their structures were assigned by detailed spectroscopic analyses and chemical conversions. Rigenolides D (1) and E (2) were elucidated to be a secoiridoid and a norsecoiridoid, respectively, possessing a dienone moiety in common. Rigenolides F-H (3-5) were assigned as acylated secoiridoid glucosides.

Keywords: Gentiana rigescens; Norsecoiridoid; Rigenolides D–H; Secoiridoid; Secoiridoid glucoside.

MeSH terms

Gentiana / chemistry*
Iridoids / chemistry*
Molecular Structure
Plant Extracts / chemistry*

Substances

Iridoids
Plant Extracts