Clinical practice guidelines are set of recommendations for cliniciansa bout the care of patients. The aim of clinical practice guidelines is to support clinical decision-making, rationalize diagnostic and therapeutic procedures and provide high-quality healthcare. Development of clinical practice guidelines should be a systematic process based on evidence based medicine (EBM). However, as practice shows, they are not always reliable and are not developed according to the recommended world-wide methodology. The purpose of this article is to provide an outline of the clinical guidelines development process and to present international instruments for guidance development, evaluation and adaptation
Keywords: Clinical practice guideline; AGREE instrument; GRADE; ADAPTE.