No differences in brain microstructure between young KIBRA-C carriers and non-carriers

Li Hu; Qunxing Xu; Jizhen Li; Feifei Wang; Xinghua Xu; Zhiyuan Sun; Xiangxing Ma; Yong Liu; Qing Wang; Dawei Wang

doi:10.18632/oncotarget.23348

No differences in brain microstructure between young KIBRA-C carriers and non-carriers

Oncotarget. 2017 Dec 16;9(1):1200-1209. doi: 10.18632/oncotarget.23348. eCollection 2018 Jan 2.

Authors

Li Hu¹, Qunxing Xu², Jizhen Li³, Feifei Wang¹, Xinghua Xu¹, Zhiyuan Sun¹, Xiangxing Ma¹, Yong Liu⁴, Qing Wang¹, Dawei Wang¹

Affiliations

¹ Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, China.
² Medical Examination Center, Qilu Hospital of Shandong University, Jinan 250012, China.
³ Mental Health Center of Shandong Province, Jinan 250012, China.
⁴ Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.

Abstract

KIBRA rs17070145 polymorphism is associated with variations in memory function and the microstructure of related brain areas. Diffusion kurtosis imaging (DKI) as an extension of diffusion tensor imaging that can provide more information about changes in microstructure, based on the idea that water diffusion in biological tissues is heterogeneous due to structural hindrance and restriction. We used DKI to explore the relationship between KIBRA gene polymorphism and brain microstructure in young adults. We recruited 100 healthy young volunteers, including 53 TT carriers and 47 C allele carriers. No differences were detected between the TT homozygotes and C-allele carriers for any diffusion and kurtosis parameter. These results indicate KIBRA rs17070145 polymorphism likely has little or no effect on brain microstructure in young adults.

Keywords: DKI; KIBRA; brain microstructure; young.