New phenolic bisabolane sesquiterpenoid derivatives with cytotoxicity from Aspergillus tennesseensis

Li Liu; Ruixing Liu; Buddha Bahadur Basnet; Li Bao; Junjie Han; Long Wang; Hongwei Liu

doi:10.1038/s41429-018-0025-3

New phenolic bisabolane sesquiterpenoid derivatives with cytotoxicity from Aspergillus tennesseensis

J Antibiot (Tokyo). 2018 May;71(5):538-542. doi: 10.1038/s41429-018-0025-3. Epub 2018 Feb 7.

Authors

Li Liu^{1

2}, Ruixing Liu^{1

2}, Buddha Bahadur Basnet^{1

3}, Li Bao^{1

2}, Junjie Han^{1

2}, Long Wang⁴, Hongwei Liu^{5

6}

Affiliations

¹ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, China.
² Savaid Medicine School, University of Chinese Academy of Sciences, Beijing, 100049, China.
³ International College, University of Chinese Academy of Sciences, Beijing, 100049, China.
⁴ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, China. wl_dgk@sina.com.
⁵ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, China. liuhw@im.ac.cn.
⁶ Savaid Medicine School, University of Chinese Academy of Sciences, Beijing, 100049, China. liuhw@im.ac.cn.

PMID: 29416122
DOI: 10.1038/s41429-018-0025-3

Abstract

Three new bisabolane sesquiterpenoid esters, aspertenols A-B (1-3), and six known compounds (4-9) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were elucidated by extensive spectroscopic analysis. The cytotoxicities of 1-9 against A549, K562, and ASPC cell lines were tested by using the CCK8 method. Compounds 1, 3, 4, 6, 7, and 9 showed inhibition on K562 cell line with IC₅₀ values in the range from 16.6 to 72.7 μM. Compounds 1, 4, and 9 showed moderate inhibitory activity against A549 with IC₅₀ of 43.5, 70.2, and 61.1 μM, respectively.

MeSH terms

Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology*
Aspergillus / chemistry*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Fermentation
Humans
Magnetic Resonance Spectroscopy
Molecular Conformation
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology*
Sincalide / antagonists & inhibitors

Substances

Antibiotics, Antineoplastic
Sesquiterpenes
Sincalide