Commercial alpha-emitting sources are fabricated mainly in a disc type. An alpha particle irradiator in Radiation Bioengineering Laboratory at Seoul National University was installed with an Am-241 disc source. Commercial Am-241 disc sources are fabricated by incorporating the radioactive element into a thin substrate layer. Those disc sources are utilized assuming that the radioactive element is uniformly distributed in the active layer of disc sources. In this study, we employed peeled-off Gafchromic EBT3 films to investigate the uniformity of areal radioactivity density over the disc source and to measure the effect of non-uniform activity distribution on dose distribution at the bottom of the cell culture dish positioned in a varying distance from the source. The measurements with the peeled-off EBT3 films informed that the areal activity density in the disc source differed by up to approximately 45% from the average. However, the inhomogeneous Am-241 distribution in a disc source did not affect the radial distribution of fluence rate at the inner bottom of cell dish when the dish is apart from the source sufficiently. The dose distribution measured with an EBT3 film nearly accorded with that obtained by Monte Carlo simulation assuming the uniform Am-241 activity distribution in the active layer of the disc source. Finally, the dose to a single-cell layer of 5 μm in a nominal thickness was obtained by Monte Carlo simulation assuming a uniform Am-241 activity distribution in the disc source at distances of 20 and 30 mm from the source. The cellular dose estimates were higher than the film dose estimates at all radial distances. The cellular dose decreased with an increasing radial distance from the center to a smaller extent than the EBT3 film dose did.
Keywords: Activity distribution; Alpha particle irradiator; Dose distribution; EBT film dosimetry; RI disc source.
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