Hyaluronan based materials with catanionic sugar-derived surfactants as drug delivery systems

Abstract

In the present work novel drug delivery systems consisting in highly porous Hyaluronan foams for the administration of a non-steroidal anti-inflammatory drug (NSAID), ketoprofen, have been obtained. A sugar-derived surfactant associated with ketoprofen was prepared and incorporated into the porous hyaluronan materials. The association between a lactose derived surfactant, Lhyd₁₂, and ketoprofen was obtained by acid-base reaction and its physicochemical properties were studied. Tensiometric and dynamic light scattering (DLS) determinations showed the formation of catanionic surfactant aggregates, Lhyd₁₂/ketoprofen, in aqueous solution. Furthermore, the catanionic surfactants allowed greater solubilisation of ketoprofen. Hyaluronan porous materials were developed using butanediol diglycidyl ether as crosslinking agent. The profile release of Lhyd₁₂/ketoprofen from hyaluronan based materials shows differences as a function of the aggregation state of catanionic surfactant.

Keywords: Catanionic surfactant; Controlled release; Crosslinked hydrogel; Highly concentrated emulsion; Hyaluronan; Ketoprofen; Solid foam.