[Yb(AAZTA)(H2O)]-: an unconventional ParaCEST MRI probe

Daniela Delli Castelli; Lorenzo Tei; Fabio Carniato; Silvio Aime; Mauro Botta

doi:10.1039/c8cc00193f

[Yb(AAZTA)(H₂O)]^-: an unconventional ParaCEST MRI probe

Chem Commun (Camb). 2018 Feb 20;54(16):2004-2007. doi: 10.1039/c8cc00193f.

Authors

Daniela Delli Castelli¹, Lorenzo Tei, Fabio Carniato, Silvio Aime, Mauro Botta

Affiliation

¹ Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Centre, University of Torino, Via Nizza 52, 10126 Torino, Italy. silvio.aime@unito.it.

PMID: 29411832
DOI: 10.1039/c8cc00193f

Abstract

An unexpectedly slow exchange rate has been observed for the coordinated water molecule of [Yb(AAZTA)(H₂O)]^- using ¹H-NMR and CEST-MRI studies. This made it possible for the first time to exploit the bound water molecule of a Ln^III complex with carboxylic donor groups for CEST imaging. This result envisages the development of a new family of thermodynamically stable ParaCEST probes based on anionic chelates.