APOE ε4 is also required in TREM2 R47H variant carriers for Alzheimer's disease to develop

Neuropathol Appl Neurobiol. 2019 Feb;45(2):183-186. doi: 10.1111/nan.12474. Epub 2018 Mar 1.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / pathology*
  • Apolipoprotein E4 / genetics*
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Membrane Glycoproteins / genetics*
  • Microglia / pathology
  • Receptors, Immunologic / genetics*

Substances

  • Apolipoprotein E4
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM2 protein, human