A new cadinane sesquiterpenoid glucoside with cytotoxicity from Abelmoschus sagittifolius

Nat Prod Res. 2019 Jun;33(12):1699-1704. doi: 10.1080/14786419.2018.1431635. Epub 2018 Feb 6.

Abstract

A new cadinane sesquiterpenoid glucoside, 2β,7,3-trihydroxycalamenene 3-O-β-d-glucoside (1) together with six known compounds, N-(p-trans-coumaroyl)-N-methyl tyramine (2), Cleomiscosin A (3), 9,12,13-trihydroxy-10,15-heptadecadienoic acid (4), Cytochalasin B (5), Marmesinin (6) and N-(p-trans-coumaroyl) tyramine (7) were obtained from the stem bark of Abelmoschus sagittifolius. The new structure of compound 1 was elucidated by analysing its 1H and 13C-NMR, 1H-1H COSY, HSQC, HMBC, NOESY and HR-ESI-MS spectra. Compounds 1-7 showed moderate cytotoxicity against Hela and HepG-2 human cancer cell lines.

Keywords: cytotoxicity; sesquiterpenoid.

MeSH terms

  • Abelmoschus / chemistry*
  • Cell Line, Tumor
  • Glucosides / chemistry
  • Glucosides / isolation & purification
  • HeLa Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Plant Extracts / chemistry
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Sesquiterpenes / toxicity

Substances

  • Glucosides
  • Plant Extracts
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • cadinane