One out of every two men and one out of every three women greater than the age of 40 will experience an acute myocardial infarction (AMI) at some time during their lifetime. As more patients survive their AMIs, the incidence of congestive heart failure (CHF) is increasing. 6 million people in the USA have ischemic cardiomyopathies and CHF. The search for new and innovative treatments for patients with AMI and CHF has led to investigations and use of human embryonic stem cells, cardiac stem/progenitor cells, bone marrow-derived mononuclear cells and mesenchymal stem cells for treatment of these heart conditions. This paper reviews current investigations with human embryonic, cardiac, bone marrow and mesenchymal stem cells, and also stem cell paracrine factors and exosomes.
Keywords: Pim-1; acute myocardial infarction; anti-inflammatory cytokines; c-kit cardiac stem/progenitor cells; cardiomyopathy; cardiopoietic mesenchymal stem cells; cardiosphere-derived cells; congestive heart failure; embryonic stem cells; exosomes; growth factors; mesenchymal stem cells; paracrine factors.