The mismatching between permittivities of guided mode and air limits the operation of accurately monitoring the change in the refractive index of the surrounding air. To solve it, we propose a platform using a hollow core fiber with the integration of graphene coating. Experimental results demonstrate that the anti-resonant reflecting guidance has been enhanced while it induces sharply and periodically lossy dips in the transmission spectrum. We conclude a sensitivity of -365.9 dB/RIU and a high detection limit of 2.73 × 10-6 RIU by means of interrogating the intensity of the lossy dips. We believe that this configuration opens a direction for highly sensitive sensing in researches of chemistry, medicine, and biology.