Effect of Maternal Smoking on Plasma and Urinary Measures of Vitamin E Isoforms in the First Month after Extreme Preterm Birth

Cosby Stone Jr; Yunping Qiu; Irwin J Kurland; James C Slaughter; Paul Moore; Joan Cook-Mills; Tina Hartert; Judy L Aschner

doi:10.1016/j.jpeds.2017.12.062

Effect of Maternal Smoking on Plasma and Urinary Measures of Vitamin E Isoforms in the First Month after Extreme Preterm Birth

J Pediatr. 2018 Jun:197:280-285.e3. doi: 10.1016/j.jpeds.2017.12.062. Epub 2018 Feb 2.

Authors

Cosby Stone Jr¹, Yunping Qiu², Irwin J Kurland², James C Slaughter³, Paul Moore⁴, Joan Cook-Mills⁵, Tina Hartert⁶, Judy L Aschner⁷

Affiliations

¹ Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN. Electronic address: cosby.a.stone@vanderbilt.edu.
² Department of Medicine, Stable Isotope and Metabolomics Core Facility, Diabetes Center, Albert Einstein College of Medicine, Bronx, NY.
³ Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN.
⁴ Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN.
⁵ Division of Allergy-Immunology, Department of Medicine, Northwestern University School of Medicine, Chicago, IL.
⁶ Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
⁷ Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine and the Children's Hospital at Montefiore, Bronx, NY.

Abstract

We examined the effect of maternal smoking on plasma and urinary levels of vitamin E isoforms in preterm infants. Maternal smoking during pregnancy decreased infant plasma alpha- and gamma-tocopherol concentrations at 1 week and 4 weeks, with 45% of infants of smokers deficient in alpha-tocopherol at 1 month after birth.

Keywords: alpha-tocopherol; gamma-tocopherol; pregnancy; prematurity; preterm; smoking; vitamin E.

Publication types

Multicenter Study
Observational Study
Research Support, N.I.H., Extramural

MeSH terms

Adult
Biomarkers / metabolism
Female
Humans
Infant, Extremely Premature / metabolism*
Infant, Newborn
Male
Oxidative Stress / physiology
Pregnancy
Prenatal Exposure Delayed Effects / metabolism*
Prospective Studies
Risk Factors
Smoking / adverse effects*
Vitamin E / metabolism*

Substances

Biomarkers
Vitamin E

Abstract

Publication types

MeSH terms

Substances

Grants and funding