Impact of Clinical and Laboratory Standards Institute breakpoint changes on susceptibility rates of cephalosporins in uncomplicated urinary tract infections caused by Enterobacteriaceae

Kristen L Bunnell; Eric Wenzler; Amanda T Harrington; Larry H Danziger

doi:10.1016/j.diagmicrobio.2017.12.007

Impact of Clinical and Laboratory Standards Institute breakpoint changes on susceptibility rates of cephalosporins in uncomplicated urinary tract infections caused by Enterobacteriaceae

Diagn Microbiol Infect Dis. 2018 Apr;90(4):335-336. doi: 10.1016/j.diagmicrobio.2017.12.007. Epub 2017 Dec 16.

Authors

Kristen L Bunnell¹, Eric Wenzler², Amanda T Harrington³, Larry H Danziger⁴

Affiliations

¹ University of Illinois at Chicago College of Pharmacy, Department of Pharmacy Practice, 833 S. Wood Street Room 164 MC 886, Chicago, IL 60612. Electronic address: kbunnell@mcw.edu.
² University of Illinois at Chicago College of Pharmacy, Department of Pharmacy Practice, 833 S. Wood Street Room 164 MC 886, Chicago, IL 60612. Electronic address: wenzler@uic.edu.
³ Loyola University Medical Center, Department of Pathology, 2160 S. First Ave, Maywood, IL 60153. Electronic address: amanda.harrington@lumc.edu.
⁴ University of Illinois at Chicago College of Pharmacy, Department of Pharmacy Practice, 833 S. Wood Street Room 164 MC 886, Chicago, IL 60612. Electronic address: danziger@uic.edu.

PMID: 29395714
DOI: 10.1016/j.diagmicrobio.2017.12.007

Abstract

Breakpoint changes may impact cephalosporin susceptibility rates in uncomplicated urinary tract infections (uUTIs). Applying the ≤16-mg/L breakpoint to urine cultures from adult women in an academic health system resulted in cefazolin being the most active uUTI antimicrobial, with 86.9% susceptibility, compared to levofloxacin (80%), nitrofurantoin (76.5%), and sulfamethoxazole-trimethoprim (72.6%).

MeSH terms

Academic Medical Centers
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / pharmacology*
Cephalosporins / pharmacology*
Drug Resistance, Bacterial*
Enterobacteriaceae / drug effects*
Enterobacteriaceae / isolation & purification
Enterobacteriaceae Infections / epidemiology
Enterobacteriaceae Infections / microbiology*
Female
Humans
Illinois
Microbial Sensitivity Tests / methods*
Microbial Sensitivity Tests / standards
Middle Aged
Prevalence
Urinary Tract Infections / epidemiology
Urinary Tract Infections / microbiology*
Young Adult

Substances

Anti-Bacterial Agents
Cephalosporins