RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT p-Methylanisole, CAS Registry Number 104-93-8

A M Api; D Belsito; D Botelho; D Browne; M Bruze; G A Burton Jr; J Buschmann; M L Dagli; M Date; W Dekant; C Deodhar; M Francis; A D Fryer; K Joshi; S La Cava; A Lapczynski; D C Liebler; D O'Brien; R Parakhia; A Patel; T M Penning; G Ritacco; J Romine; D Salvito; T W Schultz; I G Sipes; Y Thakkar; E H Theophilus; A K Tiethof; Y Tokura; S Tsang; J Wahler

doi:10.1016/j.fct.2018.01.041

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT p-Methylanisole, CAS Registry Number 104-93-8

Food Chem Toxicol. 2018 May:115 Suppl 1:S241-S247. doi: 10.1016/j.fct.2018.01.041. Epub 2018 Feb 1.

Authors

A M Api¹, D Belsito², D Botelho³, D Browne³, M Bruze⁴, G A Burton Jr⁵, J Buschmann⁶, M L Dagli⁷, M Date³, W Dekant⁸, C Deodhar³, M Francis³, A D Fryer⁹, K Joshi³, S La Cava³, A Lapczynski³, D C Liebler¹⁰, D O'Brien³, R Parakhia³, A Patel³, T M Penning¹¹, G Ritacco³, J Romine³, D Salvito³, T W Schultz¹², I G Sipes¹³, Y Thakkar³, E H Theophilus³, A K Tiethof³, Y Tokura¹⁴, S Tsang³, J Wahler³

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. Electronic address: AApi@rifm.org.
² Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY 10032, USA.
³ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
⁴ Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden.
⁵ School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI 58109, USA.
⁶ Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany.
⁷ University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil.
⁸ University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078 Würzburg, Germany.
⁹ Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.
¹⁰ Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, USA.
¹¹ University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA 19104-3083, USA.
¹² The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN 37996- 4500, USA.
¹³ Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA.
¹⁴ Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

PMID: 29395419
DOI: 10.1016/j.fct.2018.01.041

No abstract available

Keywords: Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergencity; Repeated dose, developmental and reproductive toxicity; Skin sensitization.

Publication types

Review

MeSH terms

Animals
Anisoles / administration & dosage
Anisoles / chemistry*
Anisoles / toxicity*
Consumer Product Safety
Databases, Chemical*
Drug Administration Routes
Endpoint Determination
Humans
No-Observed-Adverse-Effect Level
Perfume / administration & dosage
Perfume / chemistry*
Perfume / toxicity*
Risk Assessment
Toxicity Tests

Substances

Anisoles
Perfume
4-methyl anisole