Non-covalent Metallo-Drugs: Using Shape to Target DNA and RNA Junctions and Other Nucleic Acid Structures

Met Ions Life Sci. 2018 Feb 5:18:/books/9783110470734/9783110470734-017/9783110470734-017.xml. doi: 10.1515/9783110470734-017.

Abstract

The most effective class of anticancer drugs in clinical use are the platins which act by binding to duplex B-DNA. Yet duplex DNA is not DNA in its active form, and many other structures are formed in cells; for example, Y-shaped fork structures are involved in DNA replication and transcription and 4-way junctions with DNA repair. In this chapter we explore how large, cationic metallo-supramolecular structures can be used to bind to these less common, yet active, nucleic acid structures.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Binding Sites
  • Coordination Complexes
  • DNA, Neoplasm / chemistry
  • DNA, Neoplasm / genetics
  • DNA, Neoplasm / metabolism*
  • Drug Design
  • G-Quadruplexes
  • Humans
  • Models, Molecular
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Nucleic Acid Conformation
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / metabolism
  • Organometallic Compounds / pharmacology*
  • RNA, Neoplasm / chemistry
  • RNA, Neoplasm / genetics
  • RNA, Neoplasm / metabolism*
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Coordination Complexes
  • DNA, Neoplasm
  • Organometallic Compounds
  • RNA, Neoplasm