Abstract
The most effective class of anticancer drugs in clinical use are the platins which act by binding to duplex B-DNA. Yet duplex DNA is not DNA in its active form, and many other structures are formed in cells; for example, Y-shaped fork structures are involved in DNA replication and transcription and 4-way junctions with DNA repair. In this chapter we explore how large, cationic metallo-supramolecular structures can be used to bind to these less common, yet active, nucleic acid structures.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Binding Sites
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Coordination Complexes
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DNA, Neoplasm / chemistry
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DNA, Neoplasm / genetics
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DNA, Neoplasm / metabolism*
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Drug Design
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G-Quadruplexes
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Humans
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Models, Molecular
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Neoplasms / drug therapy*
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Neoplasms / genetics
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Neoplasms / metabolism
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Neoplasms / pathology
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Nucleic Acid Conformation
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Organometallic Compounds / chemistry
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Organometallic Compounds / metabolism
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Organometallic Compounds / pharmacology*
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RNA, Neoplasm / chemistry
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RNA, Neoplasm / genetics
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RNA, Neoplasm / metabolism*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Coordination Complexes
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DNA, Neoplasm
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Organometallic Compounds
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RNA, Neoplasm