Abstract
Common variable immunodeficiency (CVID) is an immunodeficiency disorder with a high incidence of gastrointestinal manifestations and an increased risk of gastric carcinoma and lymphoma. This review discusses the latest advancements into the immunological, clinical and diagnostic aspects of gastric malignancies in patients with CVID. The exact molecular pathways underlying the relationships between CVID and gastric malignancies remain poorly understood. These include genetics, immune dysregulation and chronic infections by Helicobacter pylori. Further studies are needed to better stratify the risk for cancer in these patients, to elaborate surveillance programs aimed at preventing these complications, and to develop new and more effective therapeutic approaches.
Keywords:
common variable immunodeficiency; gastric cancer; human immunoglobulins; lymphoproliferative disorders.
MeSH terms
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Adenocarcinoma / diagnosis
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Adenocarcinoma / drug therapy
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Adenocarcinoma / immunology
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Adenocarcinoma / pathology*
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Adrenal Cortex Hormones / therapeutic use
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Antineoplastic Agents / therapeutic use
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B-Lymphocytes / drug effects
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B-Lymphocytes / immunology
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B-Lymphocytes / pathology
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Common Variable Immunodeficiency / diagnosis
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Common Variable Immunodeficiency / drug therapy
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Common Variable Immunodeficiency / immunology
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Common Variable Immunodeficiency / pathology*
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Decision Trees
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Disease Management
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Early Detection of Cancer
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Helicobacter pylori / pathogenicity
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Helicobacter pylori / physiology
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Humans
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Immunoglobulins / deficiency*
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Immunoglobulins / therapeutic use
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Lymphoma / diagnosis
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Lymphoma / drug therapy
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Lymphoma / immunology
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Lymphoma / pathology*
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Stomach Neoplasms / diagnosis
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Stomach Neoplasms / drug therapy
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Stomach Neoplasms / immunology
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Stomach Neoplasms / pathology*
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology
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T-Lymphocytes / pathology
Substances
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Adrenal Cortex Hormones
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Antineoplastic Agents
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Immunoglobulins