Synthesis of 5-(Trifluoromethyl)pyrazolines by Formal [4 + 1]-Annulation of Fluorinated Sulfur Ylides and Azoalkenes

Zhiyong Wang; Yanzhou Yang; Fang Gao; Zhiyong Wang; Qian Luo; Ling Fang

doi:10.1021/acs.orglett.7b03811

Synthesis of 5-(Trifluoromethyl)pyrazolines by Formal [4 + 1]-Annulation of Fluorinated Sulfur Ylides and Azoalkenes

Org Lett. 2018 Feb 16;20(4):934-937. doi: 10.1021/acs.orglett.7b03811. Epub 2018 Feb 2.

Authors

Zhiyong Wang¹, Yanzhou Yang¹, Fang Gao¹, Zhiyong Wang¹, Qian Luo², Ling Fang²

Affiliations

¹ School of Chemistry and Chemical Engineering, Chongqing University , Chongqing 401331, China.
² College of Environment and Resources, Chongqing Technology and Business University , Chongqing 400067, China.

PMID: 29393649
DOI: 10.1021/acs.orglett.7b03811

Abstract

In situ formed 1,2-diaza-1,3-dienes were used in formal [4 + 1]-annulation reactions with fluorinated sulfur ylides. This protocol provides a novel and efficient method for the synthesis of 5-(trifluoromethyl)pyrazolines in moderate to excellent yields.

Publication types

Research Support, Non-U.S. Gov't