KCa(H2 O)2 [FeIII (CN)6 ]⋅H2 O Nanoparticles as an Antimicrobial Agent against Staphylococcus aureus

Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2214-2218. doi: 10.1002/anie.201713177. Epub 2018 Feb 2.

Abstract

Biocompatible nanoparticles based on a calcium analogue of Prussian blue were designed and synthesized to take advantage of their ability to penetrate the cell membrane in Staphylococcus aureus and to undergo selective ion exchange with intracellular iron to disrupt iron metabolism in such pathogenic bacteria for antibacterial applications. KCa(H2 O)2 [FeIII (CN)6 ]⋅H2 O nanoparticles penetrate the bacterial cell membrane and sequester intracellular iron by ion exchange to form insoluble Prussian blue, thus inhibiting bacterial growth.

Keywords: Prussian blue analogue; antimicrobial activity; biocompatible nanoparticles; iron depletion; iron metabolism.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Cell Survival / drug effects
  • Crystallography, X-Ray
  • Ferrocyanides / chemistry
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / toxicity
  • Mice
  • Molecular Conformation
  • Pseudomonas aeruginosa / drug effects
  • RAW 264.7 Cells
  • Staphylococcus aureus / drug effects*

Substances

  • Anti-Bacterial Agents
  • Ferrocyanides
  • ferric ferrocyanide