Is hemoglobin A1c and perioperative hyperglycemia predictive of periprosthetic joint infection following total joint arthroplasty?: A systematic review and meta-analysis

Medicine (Baltimore). 2017 Dec;96(51):e8805. doi: 10.1097/MD.0000000000008805.

Abstract

Objective: This meta-analysis aims to determine whether hemoglobin A1c (HbA1c) and perioperative hyperglycemia are associated with the increased risk of periprosthetic joint infection following total knee and hip arthroplasty.

Methods: A systematic search is performed in Medline (1966-October 2017), PubMed (1966-October 2017), Embase (1980-October 2017), ScienceDirect (1985-October 2017), and the Cochrane Library. Only high-quality studies are selected. A meta-analysis is performed using Stata 11.0 software.

Results: Six retrospective studies including 26,901 patients meet the inclusion criteria. The present meta-analysis indicates that there are significant differences between groups in terms of perioperative random blood glucose level [weighted mean difference (WMD) = 2.365, 95% confidence interval (95% CI): 1.802-2.929, P = .000] and perioperative hemoglobin A1c level (WMD = 3.266, 95% CI: 2.858-3.674, P = .000). No significant difference is found regarding body mass index (BMI) condition between groups (WMD = 0.027, 95% CI: -0.487 to 0.541, P = .919).

Conclusion: The present meta-analysis shows that high HbA1c and perioperative hyperglycemia are associated with a higher risk of periprosthetic joint infection following total joint arthroplasty. Screening of HbA1c and perioperative blood glucose is therefore an effective method to predict deep infection.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Arthritis, Infectious / diagnosis*
  • Arthroplasty, Replacement, Hip*
  • Arthroplasty, Replacement, Knee*
  • Glycated Hemoglobin / analysis*
  • Humans
  • Hyperglycemia / blood*
  • Perioperative Care
  • Postoperative Complications / diagnosis
  • Predictive Value of Tests
  • Prosthesis-Related Infections / diagnosis*

Substances

  • Glycated Hemoglobin A