Diagnostic Testing for Zika Virus: a Postoutbreak Update

J Clin Microbiol. 2018 Mar 26;56(4):e01972-17. doi: 10.1128/JCM.01972-17. Print 2018 Apr.

Abstract

Since the emergence and dissemination of Zika virus (ZIKV) in late 2015, our understanding of the biology, transmission, clinical disease, and potential sequelae associated with infection has markedly expanded. Over the past 2 years, the number of diagnostic assays for ZIKV has increased from none in 2015 to 5 serological assays and 14 molecular assays in 2017, all with emergency use authorization granted through the U.S. Food and Drug Administration. Here we provide an update on ZIKV, addressing what we have collectively learned since the outbreak began, including a summary of currently available diagnostic assays for this virus.

Keywords: RT-PCR; Zika virus; diagnostic assays; serology.

Publication types

  • Review

MeSH terms

  • Antibodies, Viral / blood
  • Disease Outbreaks*
  • Female
  • Humans
  • Pregnancy
  • RNA, Viral / blood
  • RNA, Viral / isolation & purification
  • Real-Time Polymerase Chain Reaction
  • Serologic Tests
  • United States
  • United States Food and Drug Administration
  • Zika Virus / isolation & purification*
  • Zika Virus Infection / diagnosis*

Substances

  • Antibodies, Viral
  • RNA, Viral