Zeolitic imidazolate framework-based biosensor for detection of HIV-1 DNA

Anal Biochem. 2018 Apr 1:546:5-9. doi: 10.1016/j.ab.2018.01.017. Epub 2018 Jan 31.

Abstract

ZIF-8(zinc-methylimidazolate framework-8), one of the zeolitic imidazolate frameworks (ZIFs), as quenching platforms for detection of HIV-1 DNA, which was identified to be effective for highly sensitive detection of HIV-1 DNA. The enhanced fluorescence signal has a relationship with the ssDNA concentration, the detection limit is as low as 1.2 nmol L-1 with good selectivity. This study is an important step toward rational design of materials to achieve specific interactions between biomolecules and synthetic particle surfaces.

Keywords: Biosensor; HIV-1 DNA; Zinc-methylimidazolate framework-8.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Biosensing Techniques*
  • DNA, Viral / analysis*
  • Fluorescence
  • Fluorescent Dyes / chemistry*
  • HIV-1 / chemistry*
  • HIV-1 / isolation & purification
  • Imidazoles / chemistry*
  • Molecular Structure
  • Particle Size
  • Surface Properties
  • Zeolites / chemistry*

Substances

  • DNA, Viral
  • Fluorescent Dyes
  • Imidazoles
  • Zeolites