[Study on value of IHA in diagnosis of schistosomiasis japonica]

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2016 May 31;28(4):375-380. doi: 10.16250/j.32.1374.2015252.
[Article in Chinese]

Abstract
in English, Chinese

Objective: To evaluate the value of indirect hemagglutination test (IHA) in schistosomiasis diagnosis.

Methods: The literature concerned schistosomiasis diagnosis with IHA in the databases of Medline, CNKI, VIP and Wanfang Data from 1982 to 2014 was collected and evaluated.

Results: Totally 21 articles which were satisfied with the research criteria were analyzed with the Meta-analysis method. The IHA method had high value in schistosomiasis diagnosis, the AUCSROC of IHA in laboratory evaluation was 0.990 6, while in filed evaluation was 0.832 9, and the difference between them was significant (Z = 4.50, P < 0.05).

Conclusions: The diagnosis value of IHA in field evaluation is less than that in laboratory. In the process of the elimination of schistosomiasis, developing a new and higher sensitive reagent in schistosomiasis diagnosis is needed.

［摘要］目的 评价间接血凝试验 (IHA) 在日本血吸虫病诊断中的应用价值。方法 在Medline、中国知网、维普、万方 数据库中收集1982–2014年有关IHA诊断日本血吸虫病的相关研究文献, 采用Meta分析法进行评价。结果 有21篇符 合要求的文献纳入本研究。在实验室评估中, IHA法检测日本血吸虫病AUCSROC = 0.990 6; 但在现场应用中, AUCSROC = 0.832 9; 两者差异有统计学意义 (Z = 4.50, P < 0.05) 。结论 IHA在现场应用中的日本血吸虫病诊断价值低于在实验室 评估中的诊断价值。在消除血吸虫病阶段, 亟待开发现场应用价值高的诊断试剂。.

Keywords: IHA; Immunodiagnosis; Meta-analysis; Schistosomiasis japonica.

Publication types

  • Meta-Analysis

MeSH terms

  • Hemagglutination Tests / methods*
  • Humans
  • Schistosomiasis japonica / diagnosis*