Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production

Paraskevi Heldin; Chun-Yu Lin; Constantinos Kolliopoulos; Yen-Hsu Chen; Spyros S Skandalis

doi:10.1016/j.matbio.2018.01.017

Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production

Matrix Biol. 2019 May:78-79:100-117. doi: 10.1016/j.matbio.2018.01.017. Epub 2018 Jan 31.

Authors

Paraskevi Heldin¹, Chun-Yu Lin², Constantinos Kolliopoulos³, Yen-Hsu Chen⁴, Spyros S Skandalis⁵

Affiliations

¹ Department Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE-751 23 Uppsala, Sweden. Electronic address: evi.heldin@imbim.uu.se.
² Department Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE-751 23 Uppsala, Sweden; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
³ Department Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE-751 23 Uppsala, Sweden.
⁴ Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsin Chu, Taiwan.
⁵ Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26110 Patras, Greece.

PMID: 29374576
DOI: 10.1016/j.matbio.2018.01.017

Abstract

The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of tissues. Overexpression of hyaluronan plays pivotal roles in inflammation and cancer, and markedly high serum and tissue levels of hyaluronan are noted under such pathological conditions. This review focuses on the complexity of the regulation at transcriptional and posttranslational level of hyaluronan synthetic enzymes, and the outcome of their aberrant expression and accumulation of hyaluronan in clinical conditions, such as systemic B-cell cancers, aggressive breast carcinomas, metabolic diseases and virus infection.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation
Humans
Hyaluronan Synthases / genetics
Hyaluronan Synthases / metabolism*
Hyaluronic Acid / biosynthesis*
Hyaluronic Acid / blood
Inflammation / metabolism*
Neoplasms / metabolism*
Protein Processing, Post-Translational
Signal Transduction

Substances

Hyaluronic Acid
Hyaluronan Synthases