Synthesis, Characterization, and Evaluation of Cancer Prevention Activity of Novel Modified Heterocyclic Compounds

Asian Pac J Cancer Prev. 2018 Jan 27;19(1):247-252. doi: 10.22034/APJCP.2018.19.1.247.

Abstract

Anticancer approaches may employ change of molecular structure to enhance preventive influence of chemical agents. The present examination concerned the potential anticancer impact of modified heterocyclic compounds. A strategy was developed to combine tetrazole moieties from different diamines with 2-aminobenzoic and substituted benzoyl chloride compounds with attention to synthesis, characterization and assessment of cancer preventive activity, applying IR, 1HNMR, 13CNMR and Mass spectra.

Keywords: Cytotoxicity; heterocycles; multicomponent reactions and sodium azide.