Prediction of low-risk breast cancer using quantitative DCE-MRI and its pathological basis

Tingting Xu; Lin Zhang; Hong Xu; Sifeng Kang; Yali Xu; Xiaoyu Luo; Ting Hua; Guangyu Tang

doi:10.18632/oncotarget.22267

Prediction of low-risk breast cancer using quantitative DCE-MRI and its pathological basis

Oncotarget. 2017 Nov 1;8(69):114360-114370. doi: 10.18632/oncotarget.22267. eCollection 2017 Dec 26.

Authors

Tingting Xu¹, Lin Zhang¹, Hong Xu¹, Sifeng Kang¹, Yali Xu¹, Xiaoyu Luo¹, Ting Hua¹, Guangyu Tang¹

Affiliation

¹ Department of Radiology, Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.

Abstract

Purpose: This study aimed to evaluate the difference of mass in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) characteristics between low-risk and non-low-risk breast cancers and to explore the possible pathological basis.

Materials and methods: Approval from the institutional review board and informed consent were acquired for this study. The MR images of 104 patients with pathologically proven breast cancer (104 lesions) were prospectively analyzed. All of included patients were Chinese woman. The DCE-MRI morphologic findings, apparent diffusion coefficient (ADC) values, quantitative DCE-MRI parameters, and pathological biomarkers between the two subtypes of breast cancer were compared. The quantitative DCE-MRI parameters and ADC values were added to the morphologic features in multivariate models to evaluate diagnostic performance in predicting low-risk breast cancer. The values were further subjected to the receiver operating characteristic (ROC) curve analysis.

Results: Low-risk tumors showed significantly lower K^trans and K_epvalues (t = 2.065, P = 0.043 and t = 3.548, P = 0.001, respectively) and higher ADC value (t = 4.713, P = 0.000) than non-low-risk breast cancers. Our results revealed no significant differences in clinic data and conventional imaging findings between the two breast cancer subtypes. Adding the quantitative DCE-MRI parameters and ADC values to conventional MRI improved the diagnostic performance of MRI: The area under the ROC improved from 0.63 to 0.91. Low-risk breast cancers showed significantly lower matrix metalloproteinase (MMP)-2 expression (P = 0.000), lower MMP-9 expression (P = 0.001), and lower microvessel density (MVD) values (P = 0.008) compared with non-low-risk breast cancers. K^trans and K_ep values were positively correlated with pathological biomarkers. The ADC value showed a significant inverse correlation with pathological biomarkers.

Conclusions: The prediction parameter using K^trans, K_ep, and ADC obtained on DCE-MRI and diffusion-weighted imaging could facilitate the identification of low-risk breast cancers. Decreased biological factors, including MVD, vascular endothelial growth factor, MMP-2, and MMP-9, may explain the possible pathological basis.

Keywords: apparent diffusion coefficient; dynamic contrast enhanced magnetic resonance imaging; low-risk breast cancer; pathological basis; quantitative parameters.