A patient-specific approach to assessing blood pressure management in patients with hypertension and coronary artery disease

J Clin Hypertens (Greenwich). 2018 Feb;20(2):233-239. doi: 10.1111/jch.13191. Epub 2018 Jan 25.

Abstract

The objective was to improve the management of patients with hypertension (HTN) and coronary artery disease (CAD), utilizing a model which integrates 3 determinants of coronary blood flow (CBF)-CAD severity, diastolic blood pressure (DBP), and left ventricular (LV) mass. We validated non-parametric equations for CBF estimation in a consecutive patient sample (N = 81) with HTN and CAD. There was a highly significant correlation (r = .565; P < .01) between clinical DBP and estimated CBF. Greater LV mass and more severe CAD shifted the relationship towards less CBF at the same DBP. LV mass was more critical when DBP >70 mm Hg. Estimated changes in CBF at different DBP considering the severity of CAD and LV mass can be calculated. In summary, the severity of CAD from coronary CT or coronary angiography combined with LV mass from echocardiography permits clinicians to guide the extent of, or target for, DBP to avoid seriously compromising CBF.

Keywords: coronary artery disease; coronary blood flow; diastolic blood pressure; left ventricular mass.

MeSH terms

  • Aged
  • Blood Pressure
  • Canada / epidemiology
  • Coronary Angiography / methods
  • Coronary Artery Disease* / complications
  • Coronary Artery Disease* / diagnosis
  • Coronary Artery Disease* / physiopathology
  • Coronary Vessels* / diagnostic imaging
  • Coronary Vessels* / physiopathology
  • Correlation of Data
  • Echocardiography / methods
  • Echocardiography / statistics & numerical data
  • Female
  • Heart Ventricles* / diagnostic imaging
  • Heart Ventricles* / pathology
  • Humans
  • Hypertension* / complications
  • Hypertension* / diagnosis
  • Hypertension* / physiopathology
  • Hypertension* / therapy
  • Hypertrophy, Left Ventricular* / diagnosis
  • Hypertrophy, Left Ventricular* / etiology
  • Male
  • Middle Aged
  • Organ Size
  • Patient Care Management / standards
  • Quality Improvement
  • Retrospective Studies
  • Severity of Illness Index
  • Ventricular Dysfunction, Left* / diagnosis
  • Ventricular Dysfunction, Left* / etiology