Mass Spectrometry Using Nanomechanical Systems: Beyond the Point-Mass Approximation

Nano Lett. 2018 Mar 14;18(3):1608-1614. doi: 10.1021/acs.nanolett.7b04301. Epub 2018 Feb 7.

Abstract

The mass measurement of single molecules, in real time, is performed routinely using resonant nanomechanical devices. This approach models the molecules as point particles. A recent development now allows the spatial extent (and, indeed, image) of the adsorbate to be characterized using multimode measurements ( Hanay , M. S. , Nature Nanotechnol. , 10 , 2015 , pp 339 - 344 ). This "inertial imaging" capability is achieved through virtual re-engineering of the resonator's vibrating modes, by linear superposition of their measured frequency shifts. Here, we present a complementary and simplified methodology for the analysis of these inertial imaging measurements that exhibits similar performance while streamlining implementation. This development, together with the software that we provide, enables the broad implementation of inertial imaging that opens the door to a range of novel characterization studies of nanoscale adsorbates.

Keywords: Nanomechanical systems; frequency-shift detection; inertial imaging; mass spectrometry.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Algorithms
  • Equipment Design
  • Mass Spectrometry / instrumentation*
  • Mass Spectrometry / methods
  • Microscopy, Atomic Force
  • Nanotechnology / instrumentation*
  • Nanotechnology / methods
  • Optical Imaging
  • Software