Spectroscopic and crystallographic characterization of two cathinone derivatives: 1-(4-fluorophenyl)-2-(methylamino)pentan-1-one (4-FPD) hydrochloride and 1-(4-methylphenyl)-2-(ethylamino)pentan-1-one (4-MEAP) hydrochloride

Marcin Rojkiewicz; Piotr Kuś; Joachim Kusz; Maria Książek

doi:10.1007/s11419-017-0393-6

Spectroscopic and crystallographic characterization of two cathinone derivatives: 1-(4-fluorophenyl)-2-(methylamino)pentan-1-one (4-FPD) hydrochloride and 1-(4-methylphenyl)-2-(ethylamino)pentan-1-one (4-MEAP) hydrochloride

Forensic Toxicol. 2018;36(1):141-150. doi: 10.1007/s11419-017-0393-6. Epub 2017 Nov 17.

Authors

Marcin Rojkiewicz¹, Piotr Kuś¹, Joachim Kusz², Maria Książek²

Affiliations

¹ 1Department of Organic Synthesis, Institute of Chemistry, University of Silesia, 9 Szkolna Street, 40-006 Katowice, Poland.
² 2Department of Crystal Physics, Institute of Physics, University of Silesia, 4 Uniwersytecka Street, 40-007 Katowice, Poland.

Abstract

Purpose: In this study, we performed identification and physicochemical characterization of two cathinone derivatives, 4-FPD and 4-MEAP, found in market-available materials.

Methods: The compounds were characterized by electrospray ionization ion trap mass spectrometry (MS) in MS² and MS³ modes, gas chromatography-MS, infrared, Raman and ultraviolet-visible spectroscopies, X-ray crystallography, differential scanning calorimetry and nuclear magnetic resonance spectroscopy.

Results: We could obtain detailed and comprehensive physicochemical characterization of 4-FPD and 4-MEAP-new cathinone derivatives available on the designer drugs market.

Conclusions: Dynamic growth in the number of psychoactive substances available on the designer drug markets makes it compulsory to obtain analytical data allowing unequivocal identification of these drugs in the fastest possible way. In this study we presented analytical data useful in quick identification of the investigated compounds.

Keywords: 4-FPD; 4-MEAP; Infrared and Raman spectroscopies; Mass spectrometry; NMR spectroscopy; X-ray crystallography.