Carbon dots: emerging theranostic nanoarchitectures

Drug Discov Today. 2018 Jun;23(6):1219-1232. doi: 10.1016/j.drudis.2018.01.006. Epub 2018 Jan 31.

Abstract

Nanotechnology has gained significant interest from biomedical and analytical researchers in recent years. Carbon dots (C-dots), a new member of the carbon nanomaterial family, are spherical, nontoxic, biocompatible, and discrete particles less than 10nm in diameter. Research interest has focused on C-dots because of their ultra-compact nanosize, favorable biocompatibility, outstanding photoluminescence, superior electron transfer ability, and versatile surface engineering properties. C-dots show significant potential for use in cellular imaging, biosensing, targeted drug delivery, and other biomedical applications. Here we discuss C-dots, in terms of their physicochemical properties, fabrication techniques, toxicity issues, surface engineering and biomedical potential in drug delivery, targeting as well as bioimaging.

Publication types

  • Review

MeSH terms

  • Animals
  • Carbon* / administration & dosage
  • Carbon* / chemistry
  • Carbon* / toxicity
  • Diagnostic Imaging
  • Drug Delivery Systems
  • Gene Transfer Techniques
  • Humans
  • Nanostructures* / administration & dosage
  • Nanostructures* / chemistry
  • Nanostructures* / toxicity
  • Theranostic Nanomedicine

Substances

  • Carbon