DBU-promoted carbonylative synthesis of 1,3-oxathiolan-2-ones from propargylic alcohols with TFBen as the CO source

Jun Ying; Chao Zhou; Xiao-Feng Wu

doi:10.1039/c7ob03145a

DBU-promoted carbonylative synthesis of 1,3-oxathiolan-2-ones from propargylic alcohols with TFBen as the CO source

Org Biomol Chem. 2018 Feb 14;16(7):1065-1067. doi: 10.1039/c7ob03145a.

Authors

Jun Ying¹, Chao Zhou, Xiao-Feng Wu

Affiliation

¹ Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou 310018, People's Republic of China.

PMID: 29363708
DOI: 10.1039/c7ob03145a

Abstract

A DBU-promoted carbonylative cyclization of propargylic alcohols with sulfur was developed. Various 1,3-oxathiolan-2-ones were produced in 61-98% yields under mild conditions in the absence of metal catalysts. TFBen (benzene-1,3,5-triyl triformate) as an efficient and solid CO surrogate and S₈ as an ideal sulfur source were employed and incorporated.