Longitudinal personality change associated with cognitive decline in multiple sclerosis

Shumita Roy; Allison Drake; Tom Fuchs; Michael G Dwyer; Robert Zivadinov; Benjamin P Chapman; Bianca Weinstock-Guttman; Ralph Hb Benedict

doi:10.1177/1352458517753720

Longitudinal personality change associated with cognitive decline in multiple sclerosis

Mult Scler. 2018 Jan 1:1352458517753720. doi: 10.1177/1352458517753720. Online ahead of print.

Authors

Shumita Roy¹, Allison Drake¹, Tom Fuchs², Michael G Dwyer³, Robert Zivadinov³, Benjamin P Chapman⁴, Bianca Weinstock-Guttman¹, Ralph Hb Benedict¹

Affiliations

¹ Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA.
² Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA/Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA.
³ Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA/Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA/Center for Biomedical Imaging at Clinical Translational Science Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA.
⁴ Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.

PMID: 29363385
DOI: 10.1177/1352458517753720

Abstract

We previously reported that personality and cognition were stable over 3 years in patients with multiple sclerosis (MS). This study examined whether a longer duration would reveal evidence of emerging personality dysfunction. The NEO Five-Factor Inventory and Brief International Cognitive Assessment for MS was used to assess personality and cognition, respectively. Patients were classified as "Cog Stable" or "Cog Decline" based on cognitive deterioration over 5 years. Extraversion and Conscientiousness declined across pooled groups. Follow-up of a group by time interaction found that decline in these traits was more evident in the Cog Decline group, demonstrating a link between personality and cognitive change.

Keywords: Multiple sclerosis; cognitive decline; longitudinal; personality.