Modeling specific action potentials in the human atria based on a minimal single-cell model

Yvonne Richter; Pedro G Lind; Philipp Maass

doi:10.1371/journal.pone.0190448

Modeling specific action potentials in the human atria based on a minimal single-cell model

PLoS One. 2018 Jan 23;13(1):e0190448. doi: 10.1371/journal.pone.0190448. eCollection 2018.

Authors

Yvonne Richter¹, Pedro G Lind¹, Philipp Maass¹

Affiliation

¹ Fachbereich Physik, Universität Osnabrück, Barbarastraße 7, 49076 Osnabrück, Germany.

Abstract

We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale. By applying a nonlinear optimization procedure, a best combination of the respective time scales is determined, which allows one to reproduce specific action potentials with a given amplitude, width and shape. Possible applications for supporting clinical diagnosis are pointed out.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Action Potentials*
Heart Atria / physiopathology*
Humans
Models, Cardiovascular*

Grants and funding

Deutsche Forschungsgemeinschaft (DFG), http://www.dfg.de/foerderung/programme/, Project with reference number MA1636/8-1 to Yvonne Richter. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.