The roles of interleukins in perfusion recovery after peripheral arterial disease

Biosci Rep. 2018 Feb 13;38(1):BSR20171455. doi: 10.1042/BSR20171455. Print 2018 Feb 28.

Abstract

In peripheral arterial disease (PAD) patients, occlusions in the major arteries that supply the leg makes blood flow dependent on the capacity of neovascularization. There is no current medication that is able to increase neovascularization to the ischemic limb and directly treat the primary problem of PAD. An increasing body of evidence supports the notion that inflammation plays an important role in the vascular remodeling and perfusion recovery after PAD. Interleukins (ILs), a group of proteins produced during inflammation, have been considered to be important for angiogenesis and arteriogenesis after tissue ischemia. This review summarizes the latest clinical and experimental developments of the role of ILs in blood perfusion recovery after PAD.

Keywords: Angiogenesis; Arteriogenesis; Interleukin; Peripheral Arterial Disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arteries / physiopathology
  • Humans
  • Inflammation / blood
  • Inflammation / physiopathology*
  • Interleukins / metabolism*
  • Ischemia / blood
  • Ischemia / physiopathology*
  • Leg / blood supply
  • Leg / physiopathology
  • Peripheral Arterial Disease / blood*
  • Peripheral Arterial Disease / physiopathology
  • Regional Blood Flow / physiology
  • Vascular Remodeling / physiology

Substances

  • Interleukins