Lung cancer is one of the most important malignant tumors in the world. The morbidity and mortality rank the first in all kinds of cancer. Long non-coding RNA (lncRNA) is at least 200 nt long and has no protein coding capacity. It plays an important role in the epigenetic regulation, cell cycle regulation, the regulation of cell differentiation, and many other life activities. The studies indicate that dysregulation of lncRNAs in non-small cell lung cancer (NSCLC) tissue and blood circulation is associated with the occurrence and development of cancer. The lncRNAs play an significant role in proliferation, differentiation, migration and apoptosis of the tumor cells. Explore the potential mechanism between lncRNAs and NSCLC is beneficial for the early diagnosis, target therpy and improve prognosis. Therefore, the study aims to demonstrate the latest studies on the lncRNAs related to occurence, diagnosis, therpy and prognosis of NSCLC. It can help to deeply understanding of lncRNA, and provide new ideas for the prevention of NSCLC.
肺癌是世界上常见的恶性肿瘤之一，其发病率和死亡率都居全部恶性肿瘤的首位。长链非编码RNA（lncRNA）是一类转录长度超过200个核苷酸且无蛋白质编码功能的RNA，但在表观遗传学调控、细胞周期调控和细胞分化调控等众多生命活动中发挥重要作用。研究发现lncRNA在非小细胞肺癌（non-small cell lung cancer, NSCLC）组织和血液中异常表达，且对肿瘤细胞的增殖、迁移、侵袭和凋亡发挥了重要调节作用，与肿瘤的发生发展密切相关。探索lncRNA在NSCLC中的作用机制，有助于NSCLC的早期诊断，靶向治疗及改善预后。因此本文就lncRNA与NSCLC的发生、诊断、治疗和预后的最新研究进展做一阐述，以期为NSCLC的防治提供新思路。.
Keywords: Diagnosis; LncRNA; Lung neoplasms; Prognosis; Treatment.