Negative regulation of type I IFN signaling

Kei-Ichiro Arimoto; Sayuri Miyauchi; Samuel A Stoner; Jun-Bao Fan; Dong-Er Zhang

doi:10.1002/JLB.2MIR0817-342R

Negative regulation of type I IFN signaling

J Leukoc Biol. 2018 Jan 22. doi: 10.1002/JLB.2MIR0817-342R. Online ahead of print.

Authors

Kei-Ichiro Arimoto¹, Sayuri Miyauchi¹, Samuel A Stoner¹, Jun-Bao Fan¹, Dong-Er Zhang^{1

2

3}

Affiliations

¹ Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA.
² Division of Biological Sciences, University of California San Diego, La Jolla, California, USA.
³ Department of Pathology, University of California San Diego, La Jolla, California, USA.

PMID: 29357192
DOI: 10.1002/JLB.2MIR0817-342R

Abstract

Type I IFNs (α, β, and others) are a family of cytokines that are produced in physiological conditions as well as in response to the activation of pattern recognition receptors. They are critically important in controlling the host innate and adaptive immune response to viral and some bacterial infections, cancer, and other inflammatory stimuli. However, dysregulation of type I IFN production or response can contribute to immune pathologies termed "interferonopathies", pointing to the importance of balanced activating signals with tightly regulated mechanisms of tuning this signaling. Here, we summarize the recent advances of how type I IFN production and response are controlled at multiple levels of the type I IFN signaling cascade.

Keywords: negative regulation; type I interferon.

Publication types

Review