Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis, Structural Characterization, and Cytotoxicity Studies

Alexander G Tskhovrebov; Anna A Vasileva; Richard Goddard; Tina Riedel; Paul J Dyson; Vladimir N Mikhaylov; Tatiyana V Serebryanskaya; Viktor N Sorokoumov; Matti Haukka

doi:10.1021/acs.inorgchem.8b00072

Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis, Structural Characterization, and Cytotoxicity Studies

Inorg Chem. 2018 Feb 5;57(3):930-934. doi: 10.1021/acs.inorgchem.8b00072. Epub 2018 Jan 22.

Authors

Alexander G Tskhovrebov^{1

2}, Anna A Vasileva¹, Richard Goddard², Tina Riedel³, Paul J Dyson³, Vladimir N Mikhaylov¹, Tatiyana V Serebryanskaya⁴, Viktor N Sorokoumov¹, Matti Haukka⁵

Affiliations

¹ St. Petersburg State University , Universitetskaya Nab. 7/9, St. Petersburg, Russian Federation.
² Max-Planck-Institut für Kohlenforschung , D-45470 Mülheim/Ruhr, Germany.
³ Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne , CH-1015 Lausanne, Switzerland.
⁴ Research Institute for Physical Chemical Problems of the Belarusian State University, 14, Leningradskaya Str., 220030 Minsk, Belarus.
⁵ Department of Chemistry, University of Jyväskylä , P.O. Box 35, FI-40014 Jyväskylä, Finland.

PMID: 29356518
DOI: 10.1021/acs.inorgchem.8b00072

Abstract

Well-defined diazotates are scarce. Here we report the synthesis of unprecedented homoleptic palladium(II) diazotate complexes. The palladium(II)-mediated nitrosylation of 2-aminopyridines with NaNO₂ results in the formation of metal-stabilized diazotates, which were found to be cytotoxic to human ovarian cancer cells.

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Azo Compounds / chemistry
Azo Compounds / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Coordination Complexes / chemical synthesis
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Crystallography, X-Ray
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HEK293 Cells
Humans
Models, Molecular
Molecular Structure
Palladium / chemistry
Palladium / pharmacology*
Pyridines / chemistry
Pyridines / pharmacology*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Azo Compounds
Coordination Complexes
Pyridines
Palladium
pyridine